The research team, led by Professor Cao Shengbo, has focused on studying the pathogenesis and immune mechanisms of vector-borne zoonotic diseases, as well as developing prevention and control technologies.They have made important discoveries regarding the mechanisms by which Japanese encephalitis virus and Zika virus cause damage to the central nervous system and reproductive system. Additionally, the team has successfully developed new diagnostic reagents and vaccines for arboviruses. Their development of vaccines and diagnostic kits for porcine Japanese encephalitis has made notable contributions to the prevention and control of the disease, resulting in positive economic outcomes. As a recognition of their achievements,the team has been awarded the first prize of the Hubei Provincial Scientific and Technological Progress Award and obtained a certificate of registration for new veterinary drugs.

Fundamental veterinary pharmaceutical research center's focus encompasses the exploration of animal physiological functions and morphology, as well as the pursuit of pathogenesis-related studies. The center's contributions are particularly noteworthy in the realms of therapeutic bile acid research, investigation into stem cells, and the identification of molecuar targets for veterinary pharmaceuticals and animal health products, including those catering to the microecology of livestock and poultry. These accomplishments underscore the center's commitment to pioneering advancements that hold promise. for both scientific progress and practical applications in the fields of biomaterials, veterinary medicine, and sustainable agriculture.

The research team led by professor Huang Lingli has systematically carried out Basic and applied technology research on Development and safety evaluation of new veterinary drugs，developed more than 20 new veterinary drug substances and products, and over 40 varieties of rapid detection kits for veterinary drug residues.The team has won 1 second prize of National Technical Invention Award, 2 first prizes of Hubei Provincial Scientific and Technological Progress Award, 1 first prize of Technical Invention Award and 1 first prize of Scientific and Technological Progress Award of Ministry of Education, Obtained a total of 85 national invention patents, and over 30 national food safety standards have been implemented by the govement. These products and standards have greatly improved the innovative development of veterinary drug industry, and effectively guarantees the food safety of animal products in China.

Professor Shuhong Zhao's team has developed a high-throughput and low-cost genotyping technology. This technology enriches the key genetic variations in liquid phase through specific probes, and then uses genome sequencing for high-throughput genotyping. This technology has the advantages of flexible upgrade,large amount of information, and low detection cost, providing a new technology to solve the bottleneck problem of gene chips. In addition, based on independent liquid chip technology and the latest genome research achievements, professor Zhao’s team designed a pig 80K functional site gene chip. The chip site design integrates information on pig genome enhancers, promoters, and coding region functional mutation sites, breaking the traditional theory of linkage imbalance, and significantly improving the accuracy of breeding value evaluation. The use of the new liquid chip technology can not only reduce breeding costs but also improve breeding efficiency.

The research team led by professor Miao Yi-Liang focuses on the mechanisms of porcine early embryonic development, somatic reprogramming, pluripotency maintenance and differentiation of porcine embryonic stem cells. The team has found the epigenetic regulation of porcine fertilized and cloned embryos, including of chromatin accessibility, histone modification, DNA methylation and 3D genome architecture. These findings help to increase the pig cloning efficiency by 4.4 times, and provide an effective technical means for the rapid expansion and biological breeding of pigs.

The research team led by Prof. Xianghua Yan mainly focused on the roles of gut microbiome in several host phenotypes, including intestinal health, feed efficiency, reproductive performance, and meat quality of pigs. The team has screened the key gut microbial species and their metabolites associated with these host phenotypes from native pig resources by the use of the fecal microbiota transplantation, metagenomics, 16S rDNA/ITS gene amplicon sequencing, and metabolomics. Manipulation of these key gut microbial species and their metabolites may be the promising nutritional strategy for improving the intestinal health and economic efficiency in sustainable pig production. These relevant papers made by the team have been published in the international peer-review journals, including Cell host & Microbe,and Microbiome. The team has won the Dabeinong science and technology award, and Natural Science award of MOE.

Environmentally friendly farming is a critical issue closely tied to the green, healthy, and sustainable development of the livestock industry. According to available information, China faces an annual economic loss of approximately 30 billion yuan of pig farming due to heat stress alone. Moreover, factors such as stress-related reduction in feed conversion rates and mortality rates exert additional pressures on the environment. On the other hand, the production of about 3.8 billion tons of livestock and poultry manure annually presents an environmental challenge. In light of these concerns, we have been extensively ;involved in interdisciplinary research within the domains of animal genetics and environmental engineering. This engagement has led to the pursuit of applied basic research, focusing on the intricate interplay between genetics, anti-stress and environmental control. Additionally, we have championed the principles of green and healthy breeding practices. This dedication has resulted in the publication of over 70 scholarly papers in prestigious journals such as the International Journal of Biological Sciences, Cell Death and Disease, Analytical Chemistry, Communications Biology, and Genetics Selection Evolution, both domestically and internationally. Furthermore, the applicant's contributions have extended to securing 15 national invention patents.

The research group in veterinary public health includes two major research teams, zoonosis and food safety. The research teams of zoonosis, led by the international rabies expert Prof. Zhenfang Fu, focus on the pathogenesis as well as the development of prevention and control technology for the major zoonotic pathogens, including Mycobacterium tuberculosis, rabies virus, Japanese encephalitis virus etc. Notably, they have developed the improved rabies vaccine used for pets and sold on markets for years. The research teams of food safety focus on the major foodborne pathogens, especially Salmonella, E. coli, S. aureus, and L. Monocytogenes, and conduct the study on novel detection technologies, epidemiology investigation, risk assessment and management. The surveillance data obtained by the teams have been applied for the development of strategy by the Chinese government

Direction of Clinical Veterinary Medicine comprising 15+ experienced faculty and staff members across a wide range of disciplines, all allied in teaching, research, and clinical efforts relevant to companion animals, exotic pets and wildlife, equines, and other large animals. Research in Clinical Veterinary Medicine reflects the various disciplines represented, and concentrates on problems relevant to the causes, diagnosis and treatment of problems affecting large and small animals, economic animals, and wildlife with collaborative activities between different teams. Research areas of Clinical Veterinary medicine currently has involved: diseases of animals residing in Tibet and other high-altitude regions; agnostic specialization to conduct a series of research endeavors that delve into the molecular mechanisms and biomarkers associated with mastitis, bovine endometritis, broiler ascites syndrome, and other reproductive diseases that have a detrimental impact on the productivity of food animals; investigating pain pathophysiology and its management within the realm of veterinary medicine; epidemic disease control of ruminants; small animal disease diagnosis and management; equine and exotic animal disease diagnosis and management; companion animal oncology.